Product code RXSOL-60-6605-251
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Synthesis of phthalimides. An efficient and simple method enables the N-alkylation of aromatic cyclic imides using cesium carbonate as the base in anhydrous N,N-dimethylformamide at low
temperatures (20-70˚C). The method is compatible with base labile functional groups.
Application
The Synthesis is used to get primary amines from primary alkyl halides and is named after the German scientist Siegmund Gabriel. The reaction has been generalized for applications in the alkylation of sulfonamides and imides & their deprotection in order to obtain amines.
Other Names
PHTHALIMIDE FOR SYNTHESIS
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